〈Research Field〉Immunology
Profile プロフィール
Gabriel Nuñez earned his M.D. degree from the University of Seville, Spain and received postdoctoral training at the University of Texas Southwestern Medical Center, Dallas and Washington University in Saint Louis. In 1991, he joined the Department of Pathology at the University of Michigan in Ann Arbor where he holds the Paul de Kruif Endowed Professorship in Academic Pathology. His laboratory identified NOD1 and NOD2, the first members of the Nod-like receptor (NLR) family, a class of pattern-recognition receptors that mediate cytosolic sensing of microbial organisms. Nuñez and colleagues showed that genetic variation in a NLR family member, NOD2, is strongly associated with susceptibility to Crohn’s disease. Dr. Nuñez is the author of more than 400 scientific publications (150,000 citations; h-index: 180; Google Scholar). A prolific speaker, Dr. Nuñez has given more than 450 scientific lectures in which he was the keynote speaker in 14. He is an elected member of the National Academy of Medicine of the United States.
Research Activities 研究
- Host-microbial interactions
- Role of the microbiota in host defense and disease
- Pathogenesis of inflammatory disease
Publications 主な論⽂
- Lo BC, Kryczek I, Yu J, Vatan L, Caruso R, Matsumoto M, Sato Y, Shaw MH, Inohara N, Xie Y, Lei YL, Zou W, Núñez G. Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors. Science. 383, 62-70 (2024)
- Xu J, Pickard JM, Núñez G. FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation. Cell Rep. 43, 114609 (2024)
- Kuffa P, Pickard JM, Campbell A, Yamashita M, Schaus SR, Martens EC, Schmidt TM, Inohara N, Núñez G, Caruso R. Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont. Cell Host Microbe. 31, 2007-2022 (2023)
- Hara H, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, Núñez G. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 175, 1651-1664 (2018)
- He Y, Zeng MY, Yang D, Motro B, Núñez G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. 530, 354-7 (2016)