Profile プロフィール

I work with Prof. James Wing at CiDER on human B cells and the T cell–dependent signals that direct their differentiation. Using mass cytometry and CITE-seq, we showed that CD45RB separates classical from atypical and non-classical memory B cells, and that most SARS-CoV-2-specific memory B cells after infection or mRNA vaccination are CD45RBlo (Nature Communications, 2024). We have since developed a feeder-free culture system that differentiates naive blood B cells into germinal center–like B cells that match tonsil germinal center B cells at the protein and transcript level (Science Immunology, 2026). Working with clinical collaborators at the University of Osaka, I use these approaches to study how human B cell responses form during infection and vaccination.

Research Activities 研究

• Memory B cell heterogeneity in human blood
• In vitro induction of human germinal center B cells
• B and T cell responses to infection and vaccination

Publications 主な論⽂

1. DG Priest, MF Demir, W Ise, JB Wing. In vitro induction of human germinal center B cells. Science Immunology, 2026.
2. DG Priest, JB Wing. Heterogeneity of memory B cells in human blood. International Immunology, 2026.
3. J Tulyeu, JN Søndergaard, DG Priest, T Ebihara, H Matsumoto, MA Llamas-Covarrubias, M Imai, S Esaki, S Iwasaki, A Morita, S Yamazaki, S Sakaguchi, JB Wing. Human precursor T follicular regulatory cells are primed for differentiation into mature Tfr and disrupted during severe infections. Science Advances, 2025.
4. DG Priest, T Ebihara, J Tulyeu, JN Søndergaard, S Sakakibara, F Sugihara, S Nakao, Y Togami, J Yoshimura, H Ito, S Onishi, A Muratsu, Y Mitsuyama, H Ogura, J Oda, D Okusaki, H Matsumoto, JB Wing. Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19. Nature Communications, 2024.

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