Profile プロフィール

I am originally from Adelaide, Australia, where, under the guidance of two scientists I highly admire, Dr. Keith Shearwin and Dr. Ian Dodd, I learned the fundamentals of biochemistry in a lab that studies transcriptional regulation in bacteriophage. This basic scientific training in molecular biology continues to provide the foundation for my current studies of human immunology, where I have been lucky to work with Prof. James Wing. As we endeavour for new horizons in our understanding of adaptive immunity, I am greatly appreciative of our clinical collaborators at the University of Osaka and beyond for facilitating the pursuit of bench-to-bedside research that is both fundamental in nature and we hope, will improve the lives of patients in the future.

Research Activities 研究

• Single cell human immunology in different disease settings.
• Regulation of B cells and T cells.
• Engineering in vitro systems of human immunology

Publications 主な論⽂

1. Priest DG, Ebihara T, Tulyeu J, Søndergaard JN, Sakakibara S, Sugihara F, Nakao S, Togami Y, Yoshimura J, Ito H, Onishi S, Muratsu A, Mitsuyama Y, Ogura H, Oda J, Okusaki D, Matsumoto H, Wing JB. Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19. Nat Commun. 2024;15(1):6811.
2. Tulyeu J, Søndergaard JN, Priest DG, Ebihara T, Matsumoto H, Llamas-Covarrubias MA, Imai M, Esaki S, Iwasaki S, Morita A, Yamazaki S, Sakaguchi S, Wing JB. Human precursor T follicular regulatory cells are primed for differentiation into mature Tfr and disrupted during severe infections. Sci Adv. 2025;11(39):eadv6939.
3. Søndergaard JN, Tulyeu J, Priest D, Sakaguchi S, Wing JB. Single cell suppression profiling of human regulatory T cells. Nat Commun. 2025;16(1):1325.
4. Ohno M, Ando T, Priest DG, Kumar V, Yoshida Y, Taniguchi Y. Sub-nucleosomal Genome Structure Reveals Distinct Nucleosome Folding Motifs. Cell. 2019;176(3):520-534.e25.
5. Priest DG, Cui L, Kumar S, Dunlap DD, Dodd IB, Shearwin KE. Quantitation of the DNA tethering effect in long-range DNA looping in vivo and in vitro using the Lac and λ repressors. Proceedings of the National Academy of Sciences. 2014;111(1):349-354.

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