病原体認識研究チーム
Shoichi Tachiyama
立山 翔一
特任准教授（常勤）
〈専門〉構造生物学(cryo-EM)、生化学
〈専門〉構造生物学(cryo-EM)、生化学
Profile プロフィール
- 2020年 The University of Kansas, Ph.D. in Biochemistry and Biophysics 修了
- 2020~2020年 The University of Kansas, Department of Pharmaceutical Chemistry, 博士研究員
- 2020~2026年 Yale School of Medicine, Department of Microbial Pathogenesis, 博士研究員
- 2020~2026年 Yale University, Microbial Sciences Institute, 博士研究員
- 2026年~ 大阪大学感染症総合教育研究拠点 特任准教授（常勤）
Research Activities 研究
- Cryo-electron tomography（Cryo-ET）を用いた細菌ナノマシンの構造解析および機能解析
- 赤痢菌におけるIII型分泌装置の構造および機能解析
- ピロリ菌におけるIV型分泌装置の構造および機能解析
Publications 主な論⽂
- Feng, X., Tachiyama, S., He, J., Zhu, S., Zhao, H., Botting, J. M., Liu, Y., Chen, Y., Hua, C., Lara-Tejero, M., Baker, M. A. B., Gao, X., Liu, J., & Gao, B: Structural insights into the assembly and evolution of a complex bacterial flagellar motor. Nature microbiology, 11(3), 770–785, (2026).
- Tachiyama, S., Rosinke, K., Khan, M. F., Zhou, X., Xin, Y., Botting, J. M., Yue, J., Roujeinikova, A., Hoover, T. R., & Liu, J: FlgY, PflA, and PflB form a spoke-ring network in the high-torque flagellar motor of Helicobacter pylori. Proceedings of the National Academy of Sciences of the United States of America, 122(17), e2421632122, (2025).
- Liu, X., Tachiyama, S., Zhou, X., Mathias, R. A., Bonny, S. Q., Khan, M. F., Xin, Y., Roujeinikova, A., Liu, J., & Ottemann, K. M: Bacterial flagella hijack type IV pili proteins to control motility. Proceedings of the National Academy of Sciences of the United States of America, 121(4), e2317452121, (2024).
- Tachiyama, S., Chan, K. L., Liu, X., Hathroubi, S., Peterson, B., Khan, M. F., Ottemann, K. M., Liu, J., & Roujeinikova, A: The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation. Proceedings of the National Academy of Sciences of the United States of America, 119(4), e2118401119, (2022).
- Tachiyama, S., Chang, Y., Muthuramalingam, M., Hu, B., Barta, M. L., Picking, W. L., Liu, J., & Picking, W. D: The cytoplasmic domain of MxiG interacts with MxiK and directs assembly of the sorting platform in the Shigella type III secretion system. The Journal of biological chemistry, 294(50), 19184–19196, (2019).