Assistant Director


Status : Assistant Director, Specially Appointed Prof.
Research Field : Biochemistry, Immunology

Born Hyogo Pref. Sch. of Agricultural Sciences, Univ. of Tokyo; Master of Agricultural Science (Univ. of Tokyo); PhD in Medical Sciences (Osaka Univ. 1981). JSPS Post-doc and Research Associate in Osaka Univ. Medical Sch.; Research Associate in New York Univ. Sch. of Medicine; Assistant Prof. in Osaka Univ. Medical Sch. Professor, Research Institute for Microbial Diseases (RIMD), Osaka Univ. (1990-2017); Director of RIMD (2003-2007); PI (2007-) and Deputy-Director, WPI Immunology Frontier Research Center, Osaka Univ.; Endowed Chair Prof., RIMD (2017-2022); Specially-Appointed Prof., CiDER (2022-).

Research Activities

・Studies on biological functions, biosynthesis, and deficiencies of glycosylphosphatidylinositols (GPIs), a group of glycolipids. Especially, studies on relationships between complement system and GPI, regulatory mechanisms of GPI biosynthesis, and molecular pathogenesis of acquired and inherited GPI deficiencies.


1.Wang, Y., A. K. Menon, Y. Maki, Y.-S. Liu, Y. Iwasaki, M. Fujita, P. A. Guerrero, D. Varo?n Silva, P. H. Seeberger, Y. Murakami and T. Kinoshita. 2022. Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis. Proc. Natl. Acad. Sci. USA, 119(14): e2115083119.

2.Wang, Y., Y. Maeda, Y.-S. Liu, Y. Takada, A. Ninomiya, T. Hirata, M. Fujita, Y. Murakami and T. Kinoshita. 2020. Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation. Nat. Commun., 11:860.

3.Kobayashi, A.*, T. Hirata*, T. Nishikaze, A. Ninomiya, Y. Maki, Y. Takada, T. Kitamoto and T. Kinoshita. 2020. ?2, 3-linkage of sialic acid to a GPI-anchor and an unpredicted GPI attachment site in human prion protein. J. Biol. Chem., 295(22):7789-7798.

4.Hoechsmann, B.*, Y. Murakami*, M. Osato*, A. Knaus, M. Kawamoto, N. Inoue, T. Hirata, S. Murata, M. Anliker, T. Eggerman, M. Jaeger, R. Floettmann, A. Hoellein, S. Murase, Y. Ueda, J. Nishimura, Y. Kanakura, N. Kohara, H. Schrezenmeier+, P. M. Krawitz+ and T. Kinoshita+. 2019. Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation. J. Clin. Invest., 129(12):5123-5136.

5.Hirata, T., S. K. Mishra, S. Nakamura, K. Saito, D. Motooka, Y. Takada, N. Kanzawa, Y. Murakami, Y. Maeda, M. Fujita, Y. Yamaguchi and T. Kinoshita. 2018. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Nat. Commun., 9:405.

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