Researchers
Division of Microbiology and Immunology
Divisional Director
Divisional Director
TAKEDA Kiyoshi
Status : Prof.
Research Field : Mucosal Immunity, Immune Disorder, Immune Regulation
Profile
1992 graduated Osaka University, Medical School
1998 obtained PhD degree at Graduate School of Medicine, Osaka University
1998 Research Associate Department of Biochemistry, Hyogo College of Medicine, Hyogo
1999 Research Associted Research Institute for Microbial Diseases, Osaka University
2003 Professor Medical Institute of Bioregulation, Kyushu University
2007 Professor Graduate School of Medicine, Osaka University
2007 Professor Immunology Frontier Research Center, Osaka University
2019 Director Immunology Frontier Research Center, Osaka University
Research Activities
・Study of the mechanisms regulating intestinal homeostasis for elucidation of the pathogenesis of inflammatory bowel diseases
Publications
1. Kayama H, Okumura R, Takeda K: Interaction between the microbiota, epithelia, and immune cells in the intestine. Annu. Rev. Immunol. 38, 23-48 (2020).
2. Morita N, Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A, Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R, Takeda K: GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites. Nature 566,110-114 (2019).
3. Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K: Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532, 117-121 (2016).
4. Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K: Ectoenzyme E-NPP3 (CD203c) negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity 42, 279-293 (2015).