Division of Microbiology and Immunology

Regulation of Host Defense Team

Team Leader


Status : Assoc.Prof.
Research Field :Immunology, Cell differentiation

1997 Graduate School of Agricultural and Life Sciences, The University of Tokyo
1997 Special Postdoctoral Researcher, RIKEN
1999 Research Assistant, Research Institute for Biomedical Sciences, Tokyo University of Science
2004 Post Doctoral Fellow - Research specialist, Howard Hughes Medical Institute, Department of Immunology, Washington University in St.Louis
2012 Assistant Prof. and Asssoc. Prof., Research Institute for Microbial Diseases, Osaka University.
Oct, 2022- Asssoc. Prof., CiDER, Osaka University.

Research Activities

・Mechanisms of lung tissue repair from damage caused by viral infection.

・Analysis of molecular mechanisms of tissue homeostasis regulated by epithelial cells.

・Analysis of the differentiation mechanism of tissue macrophages and their functions in vivo.


1.Kohyama M SACS -Cov-2 ORF8 is a viral cytokine regulating immnune responses. Int Immunol. 35(1):43-52. 2023.

2.Kayama H*, Kohyama M*, Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. *equally contributed. Proc. Natl. Acad. Sci. USA. 115(33):8418-8423. 2018.

3.Kohyama M et. al. Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα. Eur. J. Immunol. 46(5):1214-1223. 2016.

4.Haldar M, Kohyama M, Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 156(6):1223-1234. 2014.

5.Kohyama M et. .al. Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature. 457(7227):318-321. 2009.

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