Division of Microbiology and Immunology

Regulation of Host Defense Team

Team Leader

Team Leader

ISE Wataru

Status : Prof.
Research Field : Immunology

I was born and grew up in Hokkaido. I graduated from University of Tokyo and from graduate school of Agricultural and Life Sciences, University of Tokyo with a PhD in Agriculture, and joined the faculty there as as an assistant professor. After a postdoctoral fellow in Howard Hughes Medical Institute, Washington University in St. Louis, I joined IFReC, Osaka University, as a specially appointed Associate Professor, in 2011. Since April 2021, I have been a team leader of regulation of host defense team in Division of Microbiology and Immunology, CiDER, Osaka University.

Research Activities

・Mechanisms underlying development of follicular helper T cells upon viral infection

・New vaccine design to elicit cross-reactive, neutralizing antibodies

・Mechanisms underlying long-term survival of plasma cells

・Analysis of immune memory in human


1. Tanaka et al. Nat. Immunol. 2020;21(8):950-961

2. Ise et al. Immunity 2018;48(4):702-715

3. Ise et al. PNAS. 2014;111(32):11792-11797

4. Ise et al. Nat. Immunol. 2011;12(6): 536-543

5. Ise et al. Nat. Immunol. 2010;11(2):129-135

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