Researchers
Core Research Facility
HARA Hideyuki
Status : Specially Appointed Assoc. Prof.
Research Field : Molecular biology
Profile
2005 Ph.D. in Graduate School of Medicine, The University of Tokyo
2005 Postdoctoral Researcher, The Institute of Medical Science, The University of Tokyo
2007 Researcher, National Institute of Infectious Diseases
2012 Assistant Professor, The Institute for Enzyme Research, Tokushima University
2016 Assistant Professor, Institute of Advanced Medical Sciences, Tokushima University
2023 Specially Appointed Associate Professor (Full time), Center for Infectious Disease Education and Research, Osaka University
Research Activities
・Elucidation of the pathogenesis of prion diseases
・Development of the therapy for prion diseases
Publications
1.Hara H, Miyata H, Chida J, Sakaguchi S., Strain-dependent role of copper in prion disease through binding to histidine residues in the N-terminal domain of prion protein. J Neurochem. in press, doi: 10.1111/jnc.15971.
2. Hara H, Sakaguchi S. Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion. Int. J. Mol. Sci., 22, 12439 (2021).
3. Hara H, Chida J, Uchiyama K, Pasiana AD, Takahashi E, Kido H, Sakaguchi S. Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells. Sci. Rep., 11, 10109 (2021).
4. Hara H, Chida J, Pasiana AD, Uchiyama K, Kikuchi Y, Naito T, Takahashi Y, Yamamura J, Kuromatsu H, Sakaguchi S. Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire. Int. J. Mol. Sci., 22, 3268 (2021).
5. Hara H, Miyata H, Das NR, Chida J, Yoshimochi T, Uchiyama K, Watanabe H, Kondoh G, Yokoyama T, Sakaguchi S., Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice. J. Virol., 92, e01368-17 (2018).
